7Q85

Crystal structure of human STING in complex with MD1193

Summary for 7Q85

Entry DOI	10.2210/pdb7q85/pdb
Descriptor	Stimulator of interferon genes protein, 9-[(1R,6R,8R,13E,15R,17R,18R)-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,16-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadec-13-en-8-yl]purin-6-amine (3 entities in total)
Functional Keywords	sting, antiviral, activator, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	23847.47
Authors	Smola, M.,Klima, M.,Boura, E. (deposition date: 2021-11-10, release date: 2022-10-19, Last modification date: 2024-02-07)
Primary citation	Dejmek, M.,Brazdova, A.,Otava, T.,Polidarova, M.P.,Klima, M.,Smola, M.,Vavrina, Z.,Budesinsky, M.,Dracinsky, M.,Liboska, R.,Boura, E.,Birkus, G.,Nencka, R. Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy. Eur.J.Med.Chem., 259:115685-115685, 2023 Cited by PubMed: 37567057 DOI: 10.1016/j.ejmech.2023.115685 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.359 Å)

Structure validation