7Q5O
Bromodomain-containing 2 BD2 in complex with the inhibitor CRCM5484
Summary for 7Q5O
Entry DOI | 10.2210/pdb7q5o/pdb |
Related | 7Q3F |
Descriptor | Bromodomain-containing protein 2, 2-[[11-ethanoyl-4-(furan-2-ylmethyl)-3-oxidanylidene-8-thia-4,6,11-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),5-trien-5-yl]sulfanyl]-~{N}-(2-methylpyridin-3-yl)ethanamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | epigenetic, inhibition, inhibitor, selectivity, complex, bdii, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 13622.70 |
Authors | Carrasco, K.,Betzi, S.,Morelli, X. (deposition date: 2021-11-04, release date: 2022-04-20, Last modification date: 2024-01-31) |
Primary citation | Carrasco, K.,Montersino, C.,Derviaux, C.,Saez-Ayala, M.,Hoffer, L.,Restouin, A.,Castellano, R.,Casassa, J.,Roche, P.,Pasquier, E.,Combes, S.,Morelli, X.,Collette, Y.,Betzi, S. CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation J.Med.Chem., 65:5660-5674, 2022 Cited by DOI: 10.1021/acs.jmedchem.1c02168PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.519 Å) |
Structure validation
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