7Q3B

Crystal structure of human STING in complex with 3'3'-c-(2'F,2'dA-isonucA)MP

Summary for 7Q3B

• Entry DOI: 10.2210/pdb7q3b/pdb
• Descriptor: Stimulator of interferon genes protein, 3'3'-c-(2'F,2'dA-isonucA)MP (3 entities in total)
• Functional Keywords: sting, antiviral, activator, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 23833.47

Authors

Smola, M.,Klima, M.,Boura, E. (deposition date: 2021-10-27, release date: 2022-06-15, Last modification date: 2024-02-07)

• Primary citation: Dejmek, M.,Sala, M.,Brazdova, A.,Vanekova, L.,Smola, M.,Klima, M.,Brehova, P.,Budesinsky, M.,Dracinsky, M.,Prochazkova, E.,Zavrel, M.,Simak, O.,Pav, O.,Boura, E.,Birkus, G.,Nencka, R.; Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.; Structure, 30:1146-, 2022; PubMed: 35690061; DOI: 10.1016/j.str.2022.05.012

Experimental method

X-RAY DIFFRACTION (2.55733924728 Å)