7Q29
Crystal structure of Angiotensin-1 converting enzyme C-domain in complex with dual ACE/NEP inhibitor AD013
Summary for 7Q29
| Entry DOI | 10.2210/pdb7q29/pdb |
| Descriptor | Angiotensin-converting enzyme, ZINC ION, CHLORIDE ION, ... (12 entities in total) |
| Functional Keywords | angiotensin-1 converting enzyme, dual inhibitor, nep, metalloprotease, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 71385.50 |
| Authors | Cozier, G.E.,Acharya, K.R. (deposition date: 2021-10-23, release date: 2022-02-16, Last modification date: 2024-01-31) |
| Primary citation | Arendse, L.B.,Cozier, G.E.,Eyermann, C.J.,Basarab, G.S.,Schwager, S.L.,Chibale, K.,Acharya, K.R.,Sturrock, E.D. Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. J.Med.Chem., 65:3371-3387, 2022 Cited by PubMed: 35113565DOI: 10.1021/acs.jmedchem.1c01924 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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