7Q1H

Variant D312N of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the substrate OMP at 1.31 Angstrom resolution

Summary for 7Q1H

• Entry DOI: 10.2210/pdb7q1h/pdb
• Descriptor: Uridine 5'-monophosphate synthase, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... (5 entities in total)
• Functional Keywords: ompd, umps, omp, lyase, nucleic acid metabolism
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 28782.08

Authors

Rabe von Pappenheim, F.,Kirck, L.L. (deposition date: 2021-10-20, release date: 2022-05-04, Last modification date: 2024-01-31)

• Primary citation: Rindfleisch, S.,Krull, M.,Uranga, J.,Schmidt, T.,Rabe von Pappenheim, F.,Kirck, L.L.,Balouri, A.,Schneider, T.,Chari, A.,Kluger, R.,Bourenkov, G.,Diederichsen, U.,Mata, R.A.,Tittmann, K.; Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis; Nat Catal, 5:332-341, 2022; DOI: 10.1038/s41929-022-00771-w

Experimental method

X-RAY DIFFRACTION (1.31 Å)