7Q1H

Variant D312N of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the substrate OMP at 1.31 Angstrom resolution

7Q1H の概要

• エントリーDOI: 10.2210/pdb7q1h/pdb
• 分子名称: Uridine 5'-monophosphate synthase, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: ompd, umps, omp, lyase, nucleic acid metabolism
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28782.08

構造登録者

Rabe von Pappenheim, F.,Kirck, L.L. (登録日: 2021-10-20, 公開日: 2022-05-04, 最終更新日: 2024-01-31)

• 主引用文献: Rindfleisch, S.,Krull, M.,Uranga, J.,Schmidt, T.,Rabe von Pappenheim, F.,Kirck, L.L.,Balouri, A.,Schneider, T.,Chari, A.,Kluger, R.,Bourenkov, G.,Diederichsen, U.,Mata, R.A.,Tittmann, K.; Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis; Nat Catal, 5:332-341, 2022; DOI: 10.1038/s41929-022-00771-w

実験手法

X-RAY DIFFRACTION (1.31 Å)