7PZC

Cryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3

Summary for 7PZC

• Entry DOI: 10.2210/pdb7pzc/pdb
• EMDB information: 13684 13685 13686 13692 13693 13699
• Descriptor: NACHT, LRR and PYD domains-containing protein 3, ADENOSINE-5'-DIPHOSPHATE, 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea (3 entities in total)
• Functional Keywords: nlrp3, cp-456.773, crid3, mcc950, aaa+ atpase, nod-like receptor, inflammasome, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 1191552.12

Authors

Hochheiser, I.V.,Pilsl, M.,Hagelueken, G.,Engel, C.,Geyer, M. (deposition date: 2021-10-12, release date: 2022-01-26, Last modification date: 2024-07-17)

• Primary citation: Hochheiser, I.V.,Pilsl, M.,Hagelueken, G.,Moecking, J.,Marleaux, M.,Brinkschulte, R.,Latz, E.,Engel, C.,Geyer, M.; Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.; Nature, 604:184-189, 2022; PubMed: 35114687; DOI: 10.1038/s41586-022-04467-w

Experimental method

ELECTRON MICROSCOPY (3.9 Å)