7PY2
Structure of pathological TDP-43 filaments from ALS with FTLD
Summary for 7PY2
Entry DOI | 10.2210/pdb7py2/pdb |
EMDB information | 13708 |
Descriptor | TAR DNA-binding protein 43 (1 entity in total) |
Functional Keywords | tdp-43, als, amyotrophic lateral sclerosis, ftd, frontotemporal dementia, ftld, frontotemporal lobar degeneration, amyloid, filament, fibril, neurodegenerative, neurodegeneration, protein fibril |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 179138.97 |
Authors | Arseni, D.,Hasegawa, H.,Murzin, A.G.,Kametani, F.,Arai, M.,Yoshida, M.,Falcon, B. (deposition date: 2021-10-08, release date: 2021-12-15, Last modification date: 2024-07-17) |
Primary citation | Arseni, D.,Hasegawa, M.,Murzin, A.G.,Kametani, F.,Arai, M.,Yoshida, M.,Ryskeldi-Falcon, B. Structure of pathological TDP-43 filaments from ALS with FTLD. Nature, 601:139-143, 2022 Cited by PubMed: 34880495DOI: 10.1038/s41586-021-04199-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.59 Å) |
Structure validation
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