7PXZ
Reduced form of SARS-CoV-2 Main Protease determined by XFEL radiation
Summary for 7PXZ
| Entry DOI | 10.2210/pdb7pxz/pdb |
| Related | 7PZQ |
| Descriptor | 3C-like proteinase nsp5, CHLORIDE ION (3 entities in total) |
| Functional Keywords | 3c-like protease, main-protease, viral replication, polyprotein maturation, viral protein |
| Biological source | Severe acute respiratory syndrome coronavirus 2 |
| Total number of polymer chains | 1 |
| Total formula weight | 33861.00 |
| Authors | Schubert, R.,Reinke, P.,Galchenkova, M.,Oberthuer, D.,Murillo, G.E.P.,Kim, C.,Bean, R.,Turk, D.,Hinrichs, W.,Middendorf, P.,Round, A.,Schmidt, C.,Mills, G.,Kirkwood, H.,Han, H.,Koliyadu, J.,Bielecki, J.,Gelisio, L.,Sikorski, M.,Kloos, M.,Vakilii, M.,Yefanov, O.N.,Vagovic, P.,de-Wijn, R.,Letrun, R.,Guenther, S.,White, T.A.,Sato, T.,Srinivasan, V.,Kim, Y.,Chretien, A.,Han, S.,Brognaro, H.,Maracke, J.,Knoska, J.,Seychell, B.C.,Brings, L.,Norton-Baker, B.,Geng, T.,Dore, A.S.,Uetrecht, C.,Redecke, L.,Beck, T.,Lorenzen, K.,Betzel, C.,Mancuso, A.P.,Bajt, S.,Chapman, H.N.,Meents, A.,Lane, T.J. (deposition date: 2021-10-08, release date: 2023-01-18, Last modification date: 2024-07-31) |
| Primary citation | Reinke, P.Y.A.,Schubert, R.,Oberthur, D.,Galchenkova, M.,Rahmani Mashhour, A.,Gunther, S.,Chretien, A.,Round, A.,Seychell, B.C.,Norton-Baker, B.,Kim, C.,Schmidt, C.,Koua, F.H.M.,Tolstikova, A.,Ewert, W.,Pena Murillo, G.E.,Mills, G.,Kirkwood, H.,Brognaro, H.,Han, H.,Koliyadu, J.,Schulz, J.,Bielecki, J.,Lieske, J.,Maracke, J.,Knoska, J.,Lorenzen, K.,Brings, L.,Sikorski, M.,Kloos, M.,Vakili, M.,Vagovic, P.,Middendorf, P.,de Wijn, R.,Bean, R.,Letrun, R.,Han, S.,Falke, S.,Geng, T.,Sato, T.,Srinivasan, V.,Kim, Y.,Yefanov, O.M.,Gelisio, L.,Beck, T.,Dore, A.S.,Mancuso, A.P.,Betzel, C.,Bajt, S.,Redecke, L.,Chapman, H.N.,Meents, A.,Turk, D.,Hinrichs, W.,Lane, T.J. SARS-CoV-2 M pro responds to oxidation by forming disulfide and NOS/SONOS bonds. Nat Commun, 15:3827-3827, 2024 Cited by PubMed: 38714735DOI: 10.1038/s41467-024-48109-3 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report
