7PX4

Crystal structure of the adenosine A2A receptor (A2A-PSB1-bRIL) in complex with preladenant conjugate PSB-2113

Summary for 7PX4

Entry DOI	10.2210/pdb7px4/pdb
Descriptor	Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, Preladenant conjugate PSB-2113, ... (7 entities in total)
Functional Keywords	gpcr, membrane protein, a2a, g protein-coupled receptor, adenosine receptor, preladenant
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	60595.07
Authors	Claff, T.,Klapschinski, T.A.,Tiruttani Subhramanyam, U.K.,Vaassen, V.J.,Schlegel, J.G.,Vielmuth, C.,Voss, J.H.,Labahn, J.,Muller, C.E. (deposition date: 2021-10-07, release date: 2022-03-02, Last modification date: 2024-01-31)
Primary citation	Claff, T.,Klapschinski, T.A.,Tiruttani Subhramanyam, U.K.,Vaassen, V.J.,Schlegel, J.G.,Vielmuth, C.,Voss, J.H.,Labahn, J.,Muller, C.E. Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates. Angew.Chem.Int.Ed.Engl., 61:e202115545-e202115545, 2022 Cited by PubMed: 35174942 DOI: 10.1002/anie.202115545 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation