7PSO
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Avadomide (CC-122)
Summary for 7PSO
| Entry DOI | 10.2210/pdb7pso/pdb |
| Related | 7PS9 |
| Descriptor | Cereblon isoform 4, ZINC ION, S-Thalidomide, ... (6 entities in total) |
| Functional Keywords | immunomodulatory imide drug, ubiquitin ligase, protein degradation, signaling protein |
| Biological source | Magnetospirillum gryphiswaldense |
| Total number of polymer chains | 3 |
| Total formula weight | 42181.38 |
| Authors | Heim, C.,Hartmann, M.D. (deposition date: 2021-09-23, release date: 2022-03-16, Last modification date: 2024-01-31) |
| Primary citation | Heim, C.,Hartmann, M.D. High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system. Acta Crystallogr D Struct Biol, 78:290-298, 2022 Cited by PubMed: 35234143DOI: 10.1107/S2059798322000092 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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