7PS9

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Iberdomide (CC-220)

7PS9 の概要

• エントリーDOI: 10.2210/pdb7ps9/pdb
• 分子名称: Cereblon isoform 4, ZINC ION, (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, ... (4 entities in total)
• 機能のキーワード: protein degradation, immunomodulatory imide drug, e3 ligase, signaling protein
• 由来する生物種: Magnetospirillum gryphiswaldense
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 42442.22

構造登録者

Heim, C.,Hartmann, M.D. (登録日: 2021-09-22, 公開日: 2022-03-16, 最終更新日: 2024-01-31)

• 主引用文献: Heim, C.,Hartmann, M.D.; High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system.; Acta Crystallogr D Struct Biol, 78:290-298, 2022; PubMed: 35234143; DOI: 10.1107/S2059798322000092

実験手法

X-RAY DIFFRACTION (1.8 Å)