7PRM

CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND 13

Summary for 7PRM

Entry DOI	10.2210/pdb7prm/pdb
Descriptor	Monoglyceride lipase, (4~{R})-1-[4-(4-fluorophenyl)phenyl]-4-[4-(furan-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	alpha/beta hydrolase, hydrolase, serine esterase;
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36023.12
Authors	Grether, U.,Gobbi, L.,Kuhn, B.,Collin, L.,Leibrock, L.,Heer, D.,Wittwer, M.,Benz, J. (deposition date: 2021-09-22, release date: 2022-02-16, Last modification date: 2024-05-01)
Primary citation	He, Y.,Schild, M.,Grether, U.,Benz, J.,Leibrock, L.,Heer, D.,Topp, A.,Collin, L.,Kuhn, B.,Wittwer, M.,Keller, C.,Gobbi, L.C.,Schibli, R.,Mu, L. Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. J.Med.Chem., 65:2191-2207, 2022 Cited by PubMed: 35089028 DOI: 10.1021/acs.jmedchem.1c01706 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation