7PRM
CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND 13
Summary for 7PRM
Entry DOI | 10.2210/pdb7prm/pdb |
Descriptor | Monoglyceride lipase, (4~{R})-1-[4-(4-fluorophenyl)phenyl]-4-[4-(furan-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | alpha/beta hydrolase, hydrolase, serine esterase; |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36023.12 |
Authors | Grether, U.,Gobbi, L.,Kuhn, B.,Collin, L.,Leibrock, L.,Heer, D.,Wittwer, M.,Benz, J. (deposition date: 2021-09-22, release date: 2022-02-16, Last modification date: 2024-05-01) |
Primary citation | He, Y.,Schild, M.,Grether, U.,Benz, J.,Leibrock, L.,Heer, D.,Topp, A.,Collin, L.,Kuhn, B.,Wittwer, M.,Keller, C.,Gobbi, L.C.,Schibli, R.,Mu, L. Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. J.Med.Chem., 65:2191-2207, 2022 Cited by PubMed: 35089028DOI: 10.1021/acs.jmedchem.1c01706 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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