7PRM

CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND 13

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Monoglyceride lipase	polymer	323	35465.5	1	UniProt (Q99685) Pfam (PF12146) In PDB	Homo sapiens (Human)	MGL,HU-K5,Lysophospholipase homolog,Lysophospholipase-like,Monoacylglycerol lipase,MAGL
2	A	(4~{R})-1-[4-(4-fluorophenyl)phenyl]-4-[4-(furan-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one	non-polymer		433.5	1	Chemie (81I)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4		water	water		18.0	312	Chemie (HOH)

Sequence modifications

A: 1 - 303 (UniProt: Q99685)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Ala 36	Lys 36	engineered mutation
Ser 169	Leu 169	engineered mutation
Ser 176	Leu 176	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35465.5
Non-Polymers*	Number of molecules	3
	Total formula weight	557.6
All*	Total formula weight	36023.1

*Water molecules are not included.