7PQV

MEK1 IN COMPLEX WITH COMPOUND 7

7PQV の概要

• エントリーDOI: 10.2210/pdb7pqv/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, 8-(2-chloranyl-4-methoxy-phenyl)-7-fluoranyl-1-piperidin-4-yl-imidazo[4,5-c]quinoline, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: mek1 mitogen-activated protein kinase 1, kinase inhibitor, anti-cancer drug, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39022.75

構造登録者

Moebitz, H. (登録日: 2021-09-20, 公開日: 2022-03-16, 最終更新日: 2024-06-19)

• 主引用文献: Poddutoori, R.,Aardalen, K.,Aithal, K.,Barahagar, S.S.,Belliappa, C.,Bock, M.,Chelur, S.,Gerken, A.,Gopinath, S.,Gruenenfelder, B.,Kiffe, M.,Krishnaswami, M.,Langowski, J.,Madapa, S.,Narayanan, K.,Pandit, C.,Panigrahi, S.K.,Perrone, M.,Potakamuri, R.K.,Ramachandra, M.,Ramanathan, A.,Ramos, R.,Sager, E.,Samajdar, S.,Subramanya, H.S.,Thimmasandra, D.S.,Venetsanakos, E.,Mobitz, H.; Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.; J.Med.Chem., 65:4350-4366, 2022; PubMed: 35195996; DOI: 10.1021/acs.jmedchem.1c02192

実験手法

X-RAY DIFFRACTION (2.13 Å)