7PQU

Ligand-bound human Kv3.1 cryo-EM structure (Lu AG00563)

Summary for 7PQU

Entry DOI	10.2210/pdb7pqu/pdb
Related	7PQT
EMDB information	13604 13605
Descriptor	Potassium voltage-gated channel subfamily C member 1, 1-(4-methylphenyl)sulfonyl-N-(1,3-oxazol-2-ylmethyl)pyrrole-3-carboxamide, POTASSIUM ION, ... (4 entities in total)
Functional Keywords	potassium ion channel, voltage gated, drug target, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	237070.60
Authors	Botte, M.,Huber, S.,Bucher, D.,Klint, J.K.,Rodriguez, D.,Tagmose, L.,Chami, M.,Cheng, R.,Hennig, M.,Abdul Rhaman, W. (deposition date: 2021-09-20, release date: 2022-08-17, Last modification date: 2023-02-15)
Primary citation	Botte, M.,Huber, S.,Bucher, D.,Klint, J.K.,Rodriguez, D.,Tagmose, L.,Chami, M.,Cheng, R.,Hennig, M.,Abdul Rahman, W. Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators. Pnas Nexus, 1:pgac083-pgac083, 2022 Cited by PubMed: 36741467 DOI: 10.1093/pnasnexus/pgac083 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.03 Å)

Structure validation