7PPG

CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 9

7PPG の概要

• エントリーDOI: 10.2210/pdb7ppg/pdb
• 分子名称: Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, N-[4-[(4R)-1-cyclopentyl-4-methyl-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, ... (5 entities in total)
• 機能のキーワード: small molecule inhibitor, nmprtase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 225191.03

構造登録者

Hillig, R.C. (登録日: 2021-09-13, 公開日: 2022-06-15, 最終更新日: 2024-01-31)

• 主引用文献: Bohnke, N.,Berger, M.,Griebenow, N.,Rottmann, A.,Erkelenz, M.,Hammer, S.,Berndt, S.,Gunther, J.,Wengner, A.M.,Stelte-Ludwig, B.,Mahlert, C.,Greven, S.,Dietz, L.,Jorissen, H.,Barak, N.,Bomer, U.,Hillig, R.C.,Eberspaecher, U.,Weiske, J.,Giese, A.,Mumberg, D.,Nising, C.F.,Weinmann, H.,Sommer, A.; A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.; Bioconjug.Chem., 33:1210-1221, 2022; PubMed: 35658441; DOI: 10.1021/acs.bioconjchem.2c00178

実験手法

X-RAY DIFFRACTION (2.13 Å)