7POZ
Crystal structure of Schistosoma mansoni HDAC8 with DMSO bound in the active site
Summary for 7POZ
| Entry DOI | 10.2210/pdb7poz/pdb |
| Descriptor | Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (6 entities in total) |
| Functional Keywords | smhdac8, histone-deacetilase, double-conformation, hydrolase |
| Biological source | Schistosoma mansoni (Blood fluke) |
| Total number of polymer chains | 1 |
| Total formula weight | 50148.05 |
| Authors | Saccoccia, F.,Ruberti, G. (deposition date: 2021-09-10, release date: 2022-08-31, Last modification date: 2024-01-31) |
| Primary citation | Saccoccia, F.,Pozzetti, L.,Gimmelli, R.,Butini, S.,Guidi, A.,Papoff, G.,Giannaccari, M.,Brogi, S.,Scognamiglio, V.,Gemma, S.,Ruberti, G.,Campiani, G. Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. J.Biol.Chem., 298:102375-102375, 2022 Cited by PubMed: 35970392DOI: 10.1016/j.jbc.2022.102375 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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