7POW

Crystal structure of phosphatidyl serine synthase (PSS) in transition state.

Summary for 7POW

• Entry DOI: 10.2210/pdb7pow/pdb
• Descriptor: CDP-diacylglycerol--serine O-phosphatidyltransferase, (2S)-2-amino-3-[[[(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-[(2R)-2,3-bis[[(Z)-octadec-9-enoyl]oxy]propoxy]-dihydroxy-lambda^5-phosphanyl]oxy-propanoic acid, CALCIUM ION, ... (9 entities in total)
• Functional Keywords: membrane protein, lipid synthase, lipid binding protein
• Biological source: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
• Total number of polymer chains: 2
• Total formula weight: 51170.10

Authors

Yildiz, O.,Centola, M. (deposition date: 2021-09-10, release date: 2021-12-08, Last modification date: 2023-03-01)

• Primary citation: Centola, M.,Betz, H.,Yildiz, O.; Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases; Nat Commun, 12:6982-, 2021; DOI: 10.1038/s41467-021-27281-w

Experimental method

X-RAY DIFFRACTION (2.51 Å)