7POU

Crystal structure of profragilysin-3 (proBFT-3) from Bacteroides fragilis in complex with hesperetin.

Summary for 7POU

• Entry DOI: 10.2210/pdb7pou/pdb
• Related: 7PND
• Descriptor: BFT-3, ZINC ION, (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one, ... (6 entities in total)
• Functional Keywords: protease, zymogen, proteolysis, enterotoxin, fragilysin, hydrolase
• Biological source: Bacteroides fragilis
• Total number of polymer chains: 2
• Total formula weight: 92210.57

Authors

Eckhard, U.,Guevara, T.,Gomis-Ruth, F.X. (deposition date: 2021-09-09, release date: 2022-09-14, Last modification date: 2024-01-31)

• Primary citation: Jimenez-Alesanco, A.,Eckhard, U.,Asencio Del Rio, M.,Vega, S.,Guevara, T.,Velazquez-Campoy, A.,Gomis-Ruth, F.X.,Abian, O.; Repositioning small molecule drugs as allosteric inhibitors of the BFT-3 toxin from enterotoxigenic Bacteroides fragilis.; Protein Sci., 31:e4427-e4427, 2022; PubMed: 36173175; DOI: 10.1002/pro.4427

Experimental method

X-RAY DIFFRACTION (2.03 Å)