7PNL

Complex between monomolecular human telomeric G-quadruplex and a sulfonamide derivative of the natural alkaloid Berberine

7PNL の概要

• エントリーDOI: 10.2210/pdb7pnl/pdb
• 分子名称: G-guadruplex DNA (23-mer), POTASSIUM ION, 4-[[1-[3-[(17-methoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,13,15,17,19-octaen-16-yl)oxy]propyl]triazol-4-yl]methoxy]benzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: drug-dna complex, telomeric g-quadruplex, dna
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8638.31

構造登録者

Bazzicalupi, C.,Gratteri, P.,Petreni, A.,Nocentini, A. (登録日: 2021-09-07, 公開日: 2022-09-21, 最終更新日: 2024-07-24)

• 主引用文献: Nocentini, A.,Di Porzio, A.,Bonardi, A.,Bazzicalupi, C.,Petreni, A.,Biver, T.,Bua, S.,Marzano, S.,Amato, J.,Pagano, B.,Iaccarino, N.,De Tito, S.,Amente, S.,Supuran, C.T.,Randazzo, A.,Gratteri, P.; Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition.; J Enzyme Inhib Med Chem, 39:2366236-2366236, 2024; PubMed: 38905127; DOI: 10.1080/14756366.2024.2366236

実験手法

X-RAY DIFFRACTION (1.83 Å)