7PKL

Mechanistic understanding of antibody masking with anti-idiotypic antibody fragments

Summary for 7PKL

• Entry DOI: 10.2210/pdb7pkl/pdb
• Descriptor: trastuzumab Heavy Chain, trastuzumab Light Chain VHH fusion, SULFATE ION, ... (4 entities in total)
• Functional Keywords: trastuzumab, vhh, nanobody, dab, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 64236.83

Authors

Hargreaves, D. (deposition date: 2021-08-25, release date: 2022-09-07, Last modification date: 2024-01-31)

• Primary citation: Orozco, C.T.,Bersellini, M.,Irving, L.M.,Howard, W.W.,Hargreaves, D.,Devine, P.W.A.,Siouve, E.,Browne, G.J.,Bond, N.J.,Phillips, J.J.,Ravn, P.,Jackson, S.E.; Mechanistic insights into the rational design of masked antibodies.; Mabs, 14:2095701-2095701, ; PubMed: 35799328; DOI: 10.1080/19420862.2022.2095701

Experimental method

X-RAY DIFFRACTION (2.35 Å)