7PKL
Mechanistic understanding of antibody masking with anti-idiotypic antibody fragments
Summary for 7PKL
Entry DOI | 10.2210/pdb7pkl/pdb |
Descriptor | trastuzumab Heavy Chain, trastuzumab Light Chain VHH fusion, SULFATE ION, ... (4 entities in total) |
Functional Keywords | trastuzumab, vhh, nanobody, dab, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 64236.83 |
Authors | Hargreaves, D. (deposition date: 2021-08-25, release date: 2022-09-07, Last modification date: 2024-01-31) |
Primary citation | Orozco, C.T.,Bersellini, M.,Irving, L.M.,Howard, W.W.,Hargreaves, D.,Devine, P.W.A.,Siouve, E.,Browne, G.J.,Bond, N.J.,Phillips, J.J.,Ravn, P.,Jackson, S.E. Mechanistic insights into the rational design of masked antibodies. Mabs, 14:2095701-2095701, Cited by PubMed: 35799328DOI: 10.1080/19420862.2022.2095701 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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