7PIM

Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with dopamine.

Summary for 7PIM

• Entry DOI: 10.2210/pdb7pim/pdb
• Related: 6ZN2 6ZVP 6ZZU 7ADG
• EMDB information: 13442
• Descriptor: Tyrosine 3-monooxygenase, Regulatory domain alpha-helix, L-DOPAMINE, ... (4 entities in total)
• Functional Keywords: tetramer, dopamine, catecholamine, brain, parkinson, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 160683.48

Authors

Bueno-Carrasco, M.T.,Cuellar, J.,Santiago, C.,Valpuesta, J.M.,Martinez, A.,Flydal, M.I. (deposition date: 2021-08-20, release date: 2021-12-22, Last modification date: 2022-02-02)

• Primary citation: Bueno-Carrasco, M.T.,Cuellar, J.,Flydal, M.I.,Santiago, C.,Krakenes, T.A.,Kleppe, R.,Lopez-Blanco, J.R.,Marcilla, M.,Teigen, K.,Alvira, S.,Chacon, P.,Martinez, A.,Valpuesta, J.M.; Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.; Nat Commun, 13:74-74, 2022; PubMed: 35013193; DOI: 10.1038/s41467-021-27657-y

Experimental method

ELECTRON MICROSCOPY (4.6 Å)