7PGU
Autoinhibited structure of human neurofibromin isoform 2 stabilized by Zinc.
Summary for 7PGU
Entry DOI | 10.2210/pdb7pgu/pdb |
EMDB information | 13396 |
Descriptor | Neurofibromin, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ZINC ION, ... (4 entities in total) |
Functional Keywords | neurofibromin, cancer, gap, ras, neurofibromatosis type 1, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 641086.15 |
Authors | Naschberger, A.,Baradaran, R.,Carroni, M.,Rupp, B. (deposition date: 2021-08-15, release date: 2021-11-17, Last modification date: 2021-11-24) |
Primary citation | Naschberger, A.,Baradaran, R.,Rupp, B.,Carroni, M. The structure of neurofibromin isoform 2 reveals different functional states. Nature, 599:315-319, 2021 Cited by PubMed: 34707296DOI: 10.1038/s41586-021-04024-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
Download full validation report![Download](https://newweb-cs.pages.dev/newweb/media/icons/dl.png)
![Download](https://newweb-cs.pages.dev/newweb/media/icons/dl.png)