7PGJ

Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-decarboxylate TamK and 10-hydroxylase RdmB, together with a single point mutation F297G

7PGJ の概要

• エントリーDOI: 10.2210/pdb7pgj/pdb
• 分子名称: Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-7-methoxy-2,4,5-tris(oxidanyl)-6,11-bis(oxidanylidene)-3,4-dihydro-1H-tetracene-1-carboxylate, ... (4 entities in total)
• 機能のキーワード: carminomycin-4-o-methyltransferase variant; chimeragenesis; aclacinomycin 10-hydroxylase, tsukubarubicin 10-decarboxylase; biosynthetic protein, biosynthetic protein
• 由来する生物種: Streptomyces peucetius; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40721.15

構造登録者

Dinis, P.,MetsaKetela, M. (登録日: 2021-08-14, 公開日: 2022-08-24, 最終更新日: 2024-02-07)

• 主引用文献: Dinis, P.,Tirkkonen, H.,Wandi, B.N.,Siitonen, V.,Niemi, J.,Grocholski, T.,Metsa-Ketela, M.; Evolution-inspired engineering of anthracycline methyltransferases.; Pnas Nexus, 2:pgad009-pgad009, 2023; PubMed: 36874276; DOI: 10.1093/pnasnexus/pgad009

実験手法

X-RAY DIFFRACTION (2.13 Å)