7PGA

Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and 10-decarboxylase TamK

Summary for 7PGA

Entry DOI	10.2210/pdb7pga/pdb
Related	1tw2
Descriptor	Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate, ... (4 entities in total)
Functional Keywords	carminomycin-4-o-methyltransferase variant; chimeragenesis; aclacinomycin 10-hydroxylase; tsukubarubicin 10-decarboxylase; biosynthetic protein, biosynthetic protein
Biological source	Streptomyces peucetius More
Total number of polymer chains	4
Total formula weight	163189.00
Authors	Dinis, P.,MetsaKetela, M. (deposition date: 2021-08-13, release date: 2022-08-24, Last modification date: 2024-02-07)
Primary citation	Dinis, P.,Tirkkonen, H.,Wandi, B.N.,Siitonen, V.,Niemi, J.,Grocholski, T.,Metsa-Ketela, M. Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2:pgad009-pgad009, 2023 Cited by PubMed: 36874276 DOI: 10.1093/pnasnexus/pgad009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.77 Å)

Structure validation