7PGA
Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and 10-decarboxylase TamK
Summary for 7PGA
Entry DOI | 10.2210/pdb7pga/pdb |
Related | 1tw2 |
Descriptor | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate, ... (4 entities in total) |
Functional Keywords | carminomycin-4-o-methyltransferase variant; chimeragenesis; aclacinomycin 10-hydroxylase; tsukubarubicin 10-decarboxylase; biosynthetic protein, biosynthetic protein |
Biological source | Streptomyces peucetius More |
Total number of polymer chains | 4 |
Total formula weight | 163189.00 |
Authors | Dinis, P.,MetsaKetela, M. (deposition date: 2021-08-13, release date: 2022-08-24, Last modification date: 2024-02-07) |
Primary citation | Dinis, P.,Tirkkonen, H.,Wandi, B.N.,Siitonen, V.,Niemi, J.,Grocholski, T.,Metsa-Ketela, M. Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2:pgad009-pgad009, 2023 Cited by PubMed: 36874276DOI: 10.1093/pnasnexus/pgad009 PDB entries with the same primary citation |
Experimental method |
Structure validation
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