7PCU
Crystal structure of YTHDF1 YTH domain in complex with ebselen
Summary for 7PCU
Entry DOI | 10.2210/pdb7pcu/pdb |
Descriptor | YTH domain-containing family protein 1, N-phenyl-2-selanylbenzamide (3 entities in total) |
Functional Keywords | mrna binding and stability, rna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 46848.72 |
Authors | Dalle Vedove, A.,Cazzanelli, G.,Quattrone, A.,Provenzani, A.,Lolli, G. (deposition date: 2021-08-04, release date: 2022-12-07, Last modification date: 2024-02-07) |
Primary citation | Micaelli, M.,Dalle Vedove, A.,Cerofolini, L.,Vigna, J.,Sighel, D.,Zaccara, S.,Bonomo, I.,Poulentzas, G.,Rosatti, E.F.,Cazzanelli, G.,Alunno, L.,Belli, R.,Peroni, D.,Dassi, E.,Murakami, S.,Jaffrey, S.R.,Fragai, M.,Mancini, I.,Lolli, G.,Quattrone, A.,Provenzani, A. Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs. Acs Pharmacol Transl Sci, 5:872-891, 2022 Cited by PubMed: 36268123DOI: 10.1021/acsptsci.2c00008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
Download full validation report