7PBE

Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope

7PBE の概要

• エントリーDOI: 10.2210/pdb7pbe/pdb
• 関連するPDBエントリー: 7P3D
• 分子名称: MHC class I antigen, Beta-2-microglobulin, Spike protein S1, ... (7 entities in total)
• 機能のキーワード: mhc i, a02, wuhan epitope, sars-cov-2, spike protein, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 191536.10

構造登録者

Rizkallah, P.J.,Sewell, A.K.,Wall, A.,Fuller, A. (登録日: 2021-08-02, 公開日: 2022-04-27, 最終更新日: 2024-11-20)

主引用文献

Dolton, G.,Rius, C.,Hasan, M.S.,Wall, A.,Szomolay, B.,Behiry, E.,Whalley, T.,Southgate, J.,Fuller, A.,Morin, T.,Topley, K.,Tan, L.R.,Goulder, P.J.R.,Spiller, O.B.,Rizkallah, P.J.,Jones, L.C.,Connor, T.R.,Sewell, A.K.
Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope.
Cell, 185:2936-, 2022

PubMed Abstract: We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein epitope (sequence YLQPRTFLL) via the most frequent human leukocyte antigen (HLA) class I worldwide, HLA A02. The Spike P272L mutation that has arisen in at least 112 different SARS-CoV-2 lineages to date, including in lineages classified as "variants of concern," was not recognized by the large CD8 T cell response seen across cohorts of HLA A02 convalescent patients and individuals vaccinated against SARS-CoV-2, despite these responses comprising of over 175 different individual T cell receptors. Viral escape at prevalent T cell epitopes restricted by high frequency HLAs may be particularly problematic when vaccine immunity is focused on a single protein such as SARS-CoV-2 Spike, providing a strong argument for inclusion of multiple viral proteins in next generation vaccines and highlighting the need for monitoring T cell escape in new SARS-CoV-2 variants.

PubMed: 35931021
DOI: 10.1016/j.cell.2022.07.002

実験手法

X-RAY DIFFRACTION (3 Å)