7PAD
The crystal structure of DW-0254 in complex with PDE6D
Summary for 7PAD
Entry DOI | 10.2210/pdb7pad/pdb |
Descriptor | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, NICKEL (II) ION, GLYCEROL, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20158.60 |
Authors | Beaumont, E.,Williams, D. (deposition date: 2021-07-29, release date: 2022-06-08, Last modification date: 2024-01-31) |
Primary citation | Canovas Nunes, S.,De Vita, S.,Anighoro, A.,Autelitano, F.,Beaumont, E.,Klingbeil, P.,McGuinness, M.,Duvert, B.,Harris, C.,Yang, L.,Pokharel, S.P.,Chen, C.W.,Ermann, M.,Williams, D.A.,Xu, H. Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects. Blood Cancer J, 12:64-64, 2022 Cited by PubMed: 35422065DOI: 10.1038/s41408-022-00663-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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