7PAD

The crystal structure of DW-0254 in complex with PDE6D

Summary for 7PAD

Entry DOI	10.2210/pdb7pad/pdb
Descriptor	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, NICKEL (II) ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	inhibitor, complex, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	20158.60
Authors	Beaumont, E.,Williams, D. (deposition date: 2021-07-29, release date: 2022-06-08, Last modification date: 2024-01-31)
Primary citation	Canovas Nunes, S.,De Vita, S.,Anighoro, A.,Autelitano, F.,Beaumont, E.,Klingbeil, P.,McGuinness, M.,Duvert, B.,Harris, C.,Yang, L.,Pokharel, S.P.,Chen, C.W.,Ermann, M.,Williams, D.A.,Xu, H. Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects. Blood Cancer J, 12:64-64, 2022 Cited by PubMed: 35422065 DOI: 10.1038/s41408-022-00663-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation