7P6Y
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH compound 5ef
This is a non-PDB format compatible entry.
Summary for 7P6Y
Entry DOI | 10.2210/pdb7p6y/pdb |
Related | 7P6V 7P6W |
Descriptor | Bromodomain-containing protein 4, 4-benzoyl-N-(2-(2-(2-((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-6-yl)(methyl)amino)ethoxy)ethoxy)ethyl)-N-(2-oxo-2-((2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)amino)ethyl)benzamide (3 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31976.85 |
Authors | Chung, C. (deposition date: 2021-07-18, release date: 2021-10-06, Last modification date: 2024-05-01) |
Primary citation | Fallon, D.J.,Lehmann, S.,Chung, C.W.,Phillipou, A.,Eberl, C.,Fantom, K.G.M.,Zappacosta, F.,Patel, V.K.,Bantscheff, M.,Schofield, C.J.,Tomkinson, N.C.O.,Bush, J.T. One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics. Chemistry, 27:17880-17888, 2021 Cited by PubMed: 34328642DOI: 10.1002/chem.202102036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.881 Å) |
Structure validation
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