7P4S

BROMODOMAIN OF HUMAN TAF1 (2) WITH naphthyridinone compound

7P4S の概要

• エントリーDOI: 10.2210/pdb7p4s/pdb
• 分子名称: Isoform 2a of Transcription initiation factor TFIID subunit 1, 8-[[1-(3-azanylpropyl)piperidin-4-yl]amino]-5-[5-(hydroxymethyl)pyridin-3-yl]-3-methyl-1~{H}-1,7-naphthyridin-2-one (3 entities in total)
• 機能のキーワード: second bromodomain of taf1, inhibitor-bound, complex, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16697.83

構造登録者

Chung, C. (登録日: 2021-07-13, 公開日: 2021-10-13, 最終更新日: 2024-01-31)

• 主引用文献: Clegg, M.A.,Theodoulou, N.H.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Demont, E.H.,Gordon, L.J.,Liwicki, G.M.,Phillipou, A.,Tomkinson, N.C.O.,Prinjha, R.K.,Humphreys, P.G.; Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors.; Acs Med.Chem.Lett., 12:1308-1317, 2021; PubMed: 34413961; DOI: 10.1021/acsmedchemlett.1c00294

実験手法

X-RAY DIFFRACTION (2.17 Å)