7P3S

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 12

7P3S の概要

• エントリーDOI: 10.2210/pdb7p3s/pdb
• 分子名称: Histone deacetylase, ZINC ION, POTASSIUM ION, ... (6 entities in total)
• 機能のキーワード: epigenetics, histone deacetylase, hdac8, selective inhibitor, pathogen, hydrolase
• 由来する生物種: Schistosoma mansoni
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 205148.73

構造登録者

Shaik, T.B.,Romier, C. (登録日: 2021-07-08, 公開日: 2021-09-15, 最終更新日: 2024-01-31)

• 主引用文献: Ghazy, E.,Heimburg, T.,Lancelot, J.,Zeyen, P.,Schmidtkunz, K.,Truhn, A.,Darwish, S.,Simoben, C.V.,Shaik, T.B.,Erdmann, F.,Schmidt, M.,Robaa, D.,Romier, C.,Jung, M.,Pierce, R.,Sippl, W.; Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.; Eur.J.Med.Chem., 225:113745-113745, 2021; PubMed: 34392190; DOI: 10.1016/j.ejmech.2021.113745

実験手法

X-RAY DIFFRACTION (1.546 Å)