7P3I
Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein
Summary for 7P3I
Entry DOI | 10.2210/pdb7p3i/pdb |
Descriptor | Tumor necrosis factor receptor superfamily member 5, Darpin, SODIUM ION, ... (4 entities in total) |
Functional Keywords | tnfrsf5, immune-oncology, cd40, unknown function |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 72840.05 |
Authors | Malvezzi, F.,Mangold, S.,Hospodarsch, T.,Reichen, C.,Iss, C.,Lammens, A.,Krapp, S.,Domke, C. (deposition date: 2021-07-07, release date: 2022-04-06, Last modification date: 2022-05-11) |
Primary citation | Rigamonti, N.,Veitonmaki, N.,Domke, C.,Barsin, S.,Jetzer, S.,Abdelmotaleb, O.,Bessey, R.,Lekishvili, T.,Malvezzi, F.,Gachechiladze, M.,Behe, M.,Levitsky, V.,Trail, P.A. A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression. Cancer Immunol Res, 10:626-640, 2022 Cited by PubMed: 35319751DOI: 10.1158/2326-6066.CIR-21-0553 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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