7P3I

Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein

7P3I の概要

• エントリーDOI: 10.2210/pdb7p3i/pdb
• 分子名称: Tumor necrosis factor receptor superfamily member 5, Darpin, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: tnfrsf5, immune-oncology, cd40, unknown function
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 72840.05

構造登録者

Malvezzi, F.,Mangold, S.,Hospodarsch, T.,Reichen, C.,Iss, C.,Lammens, A.,Krapp, S.,Domke, C. (登録日: 2021-07-07, 公開日: 2022-04-06, 最終更新日: 2022-05-11)

• 主引用文献: Rigamonti, N.,Veitonmaki, N.,Domke, C.,Barsin, S.,Jetzer, S.,Abdelmotaleb, O.,Bessey, R.,Lekishvili, T.,Malvezzi, F.,Gachechiladze, M.,Behe, M.,Levitsky, V.,Trail, P.A.; A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression.; Cancer Immunol Res, 10:626-640, 2022; PubMed: 35319751; DOI: 10.1158/2326-6066.CIR-21-0553

実験手法

X-RAY DIFFRACTION (2.29 Å)