7P2S

Crystal structure of Schistosoma mansoni HDAC8 in complex with a tricyclic thieno[3,2-b]indole capped hydroxamate-based inhibitor, chlorine derivative

Summary for 7P2S

Entry DOI	10.2210/pdb7p2s/pdb
Descriptor	Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	inhibitor histone deacetylase (hdaci), complex schistosoma mansoni hdac8 + inhibitor, active-site., hydrolase
Biological source	Schistosoma mansoni (Blood fluke)
Total number of polymer chains	1
Total formula weight	50402.33
Authors	Saccoccia, F.,Gemma, S.,Campiani, G.,Ruberti, G. (deposition date: 2021-07-06, release date: 2022-07-27, Last modification date: 2024-01-31)
Primary citation	Saccoccia, F.,Pozzetti, L.,Gimmelli, R.,Butini, S.,Guidi, A.,Papoff, G.,Giannaccari, M.,Brogi, S.,Scognamiglio, V.,Gemma, S.,Ruberti, G.,Campiani, G. Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. J.Biol.Chem., 298:102375-102375, 2022 Cited by PubMed: 35970392 DOI: 10.1016/j.jbc.2022.102375 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation