7P2L

thermostabilised 7TM domain of human mGlu5 receptor bound to photoswitchable ligand alloswitch-1

7P2L の概要

• エントリーDOI: 10.2210/pdb7p2l/pdb
• 分子名称: Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, 2-chloranyl-~{N}-[2-methoxy-4-[(~{E})-pyridin-2-yldiazenyl]phenyl]benzamide (3 entities in total)
• 機能のキーワード: g protein coupled receptor, mglu5 7tm, photoswitchable ligand, allosteric modulator, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52284.86

構造登録者

Huang, C.Y.,Vinothkumar, K.R.,Lebon, G. (登録日: 2021-07-06, 公開日: 2021-09-08, 最終更新日: 2024-01-31)

• 主引用文献: Nasrallah, C.,Cannone, G.,Briot, J.,Rottier, K.,Berizzi, A.E.,Huang, C.Y.,Quast, R.B.,Hoh, F.,Baneres, J.L.,Malhaire, F.,Berto, L.,Dumazer, A.,Font-Ingles, J.,Gomez-Santacana, X.,Catena, J.,Kniazeff, J.,Goudet, C.,Llebaria, A.,Pin, J.P.,Vinothkumar, K.R.,Lebon, G.; Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.; Cell Rep, 36:109648-109648, 2021; PubMed: 34469715; DOI: 10.1016/j.celrep.2021.109648

実験手法

X-RAY DIFFRACTION (2.54 Å)