7P2B

Crystal structure of human gelsolin amyloid mutant A551P

Summary for 7P2B

• Entry DOI: 10.2210/pdb7p2b/pdb
• Descriptor: Gelsolin, SULFATE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: gelsolin protein, actin binding protein, structural protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 172532.10

Authors

Bollati, M.,de Rosa, M. (deposition date: 2021-07-05, release date: 2022-05-18, Last modification date: 2024-01-31)

• Primary citation: Bollati, M.,Diomede, L.,Giorgino, T.,Natale, C.,Fagnani, E.,Boniardi, I.,Barbiroli, A.,Alemani, R.,Beeg, M.,Gobbi, M.,Fakin, A.,Mastrangelo, E.,Milani, M.,Presciuttini, G.,Gabellieri, E.,Cioni, P.,de Rosa, M.; A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation.; Comput Struct Biotechnol J, 19:6355-6365, 2021; PubMed: 34938411; DOI: 10.1016/j.csbj.2021.11.025

Experimental method

X-RAY DIFFRACTION (3 Å)