7P1L

The MARK3 Kinase Domain Bound To AA-CS-1-008

「7O94」から置き換えられました

7P1L の概要

• エントリーDOI: 10.2210/pdb7p1l/pdb
• 分子名称: MAP/microtubule affinity-regulating kinase 3, 5-Bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase inhibitor active site folded activation loop uba domain, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76500.09

構造登録者

Dederer, V.,Preuss, F.,Chatterjee, D.,Vlassova, A.,Mathea, S.,Axtman, A.,Knapp, S. (登録日: 2021-07-01, 公開日: 2021-07-14, 最終更新日: 2024-01-31)

• 主引用文献: Drewry, D.H.,Annor-Gyamfi, J.K.,Wells, C.I.,Pickett, J.E.,Dederer, V.,Preuss, F.,Mathea, S.,Axtman, A.D.; Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.; J.Med.Chem., 65:1313-1328, 2022; PubMed: 34333981; DOI: 10.1021/acs.jmedchem.1c00440

実験手法

X-RAY DIFFRACTION (1.95 Å)