7P1A

Carbonic Anhydrase VII Sultam Based Inhibitors

Summary for 7P1A

• Entry DOI: 10.2210/pdb7p1a/pdb
• Descriptor: Carbonic anhydrase 7, ZINC ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: carbonic anhydrase vii, inhibitor, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 31506.75

Authors

D'Ambrosio, K.,De Simone, G. (deposition date: 2021-07-01, release date: 2021-11-17)

Primary citation

Akgul, O.,Lucarini, E.,Mannelli, L.D.C.,Ghelardini, C.,D'Ambrosio, K.,Buonanno, M.,Monti, S.M.,De Simone, G.,Angeli, A.,Supuran, C.T.,Carta, F.
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.
Eur.J.Med.Chem., 227:113956-113956, 2021

PubMed Abstract: We report a series of compounds 1-17 derived from the antiepileptic drug Sulthiame (SLT) from which both the benzenesulfonamide and the sultam moiety were retained. All compounds were tested in vitro for their inhibition activity against the human (h) Carbonic Anhydrase (CA; EC 4.2.1.1) I, II, VII, IX and XII isoforms. Among the series, derivatives 1 and 11 showed great enhancement of both inhibition potency and selectivity towards the hCA VII isoform, when compared to the reference SLT drug. The binding mode of 11 within the hCA VII active site was deciphered by means of X-ray crystallography and revealed the sultam moiety being exposed to the rim of the active site. In vivo experiments on a model of neuropathic pain induced by oxaliplatin clearly showed 11 being an effective pain relieving agent and therefore worth of further exploitation towards the validation of the hCA VII as new target for the management of neuropathies.

PubMed: 34731762
DOI: 10.1016/j.ejmech.2021.113956

Experimental method

X-RAY DIFFRACTION (1.58 Å)