7P18

Crystal structure of 3-ketosteroid delta1-dehydrogenase from Sterolibacterium denitrificans in complex with 1,4-androstadiene-3,17-dione

Summary for 7P18

• Entry DOI: 10.2210/pdb7p18/pdb
• Descriptor: 3-oxosteroid 1-dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, ANDROSTA-1,4-DIENE-3,17-DIONE, ... (7 entities in total)
• Functional Keywords: flavoprotein, dehydrogenase, oxidoreductase, 3-ketosteroid delta1-dehydrogenase, 3-ketosteroid dehydrogenase, 3-oxosteroid dehydrogenase, rossmann fold
• Biological source: Sterolibacterium denitrificans
• Total number of polymer chains: 2
• Total formula weight: 125541.08

Authors

Wojcik, P.,Mrugala, B.,Kurpiewska, K.,Szaleniec, M. (deposition date: 2021-07-01, release date: 2021-07-21, Last modification date: 2024-02-07)

• Primary citation: Wojcik, P.,Glanowski, M.,Mrugala, B.,Procner, M.,Zastawny, O.,Flejszar, M.,Kurpiewska, K.,Niedzialkowska, E.,Minor, W.,Oszajca, M.,Bojarski, A.J.,Wojtkiewicz, A.M.,Szaleniec, M.; Structure, Mutagenesis, and QM:MM Modeling of 3-Ketosteroid Delta 1 -Dehydrogenase from Sterolibacterium denitrificans ─The Role of a New Putative Membrane-Associated Domain and Proton-Relay System in Catalysis.; Biochemistry, 62:808-823, 2023; PubMed: 36625854; DOI: 10.1021/acs.biochem.2c00576

Experimental method

X-RAY DIFFRACTION (1.84 Å)