7P02
Human Neurokinin 1 receptor (NK1R) substance P Gs complex
Summary for 7P02
Entry DOI | 10.2210/pdb7p02/pdb |
EMDB information | 13141 |
Descriptor | Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | receptor, complex, eukaryotic protein, membrane protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 153739.34 |
Authors | Thom, C.,Ehrenmann, J.,Vacca, S.,Waltenspuhl, Y.,Schoppe, J.,Medalia, O.,Pluckthun, A. (deposition date: 2021-06-29, release date: 2021-12-15) |
Primary citation | Thom, C.,Ehrenmann, J.,Vacca, S.,Waltenspuhl, Y.,Schoppe, J.,Medalia, O.,Pluckthun, A. Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7:eabk2872-eabk2872, 2021 Cited by PubMed: 34878828DOI: 10.1126/sciadv.abk2872 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.87 Å) |
Structure validation
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