7P02
Human Neurokinin 1 receptor (NK1R) substance P Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Antibody fragment scFv16 | polymer | 298 | 32409.2 | 1 | Mus musculus (Mouse) | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 354 | 39086.6 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 246 | 28428.4 | 1 | UniProt (P63096) UniProt (P63092) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein,Adenylate cyclase-stimulating G alpha protein |
| 5 | E (R) | Substance-P receptor | polymer | 382 | 44218.7 | 1 | UniProt (P25103) Pfam (PF00001) | Homo sapiens (Human) | SPR,NK-1 receptor,NK-1R,Tachykinin receptor 1 |
| 6 | F (P) | Protachykinin-1 | polymer | 12 | 1348.6 | 1 | UniProt (P20366) Pfam (PF02202) | Homo sapiens (Human) | PPT, Substance P |
| 7 | G (R) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
A: 1 - 19 (UniProt: P63096)
A: 197 - 377 (UniProt: P63092)
R: 1 - 335 (UniProt: P25103)
P: 1 - 11 (UniProt: P20366)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 20 | - | linker |
| Lys 21 | - | linker |
| Gln 22 | - | linker |
| Leu 23 | - | linker |
| Gln 24 | - | linker |
| Lys 25 | - | linker |
| Asp 26 | - | linker |
| Lys 27 | - | linker |
| Gln 28 | - | linker |
| Val 29 | - | linker |
| Tyr 30 | - | linker |
| Arg 31 | - | linker |
| Ala 32 | - | linker |
| Thr 33 | - | linker |
| His 34 | - | linker |
| Arg 35 | - | linker |
| Leu 36 | - | linker |
| Leu 37 | - | linker |
| Leu 38 | - | linker |
| Leu 39 | - | linker |
| Gly 40 | - | linker |
| Ala 41 | - | linker |
| Asp 42 | - | linker |
| Asn 43 | - | linker |
| Ser 44 | - | linker |
| Gly 45 | - | linker |
| Lys 46 | - | linker |
| Ser 47 | - | linker |
| Thr 48 | - | linker |
| Ile 49 | - | linker |
| Val 50 | - | linker |
| Lys 182 | - | linker |
| Gln 183 | - | linker |
| Met 184 | - | linker |
| Arg 185 | - | linker |
| Ile 186 | - | linker |
| Leu 187 | - | linker |
| His 188 | - | linker |
| Gly 189 | - | linker |
| Gly 190 | - | linker |
| Ser 191 | - | linker |
| Gly 192 | - | linker |
| Gly 193 | - | linker |
| Ser 194 | - | linker |
| Gly 195 | - | linker |
| Gly 196 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asp 242 | Ala 249 | conflict |
| Asp 245 | Ser 252 | conflict |
| - | Asn 254 | deletion |
| - | Met 255 | deletion |
| - | Val 256 | deletion |
| - | Ile 257 | deletion |
| - | Arg 258 | deletion |
| - | Glu 259 | deletion |
| - | Asp 260 | deletion |
| - | Asn 261 | deletion |
| - | Gln 262 | deletion |
| - | Thr 263 | deletion |
| Ala 355 | Ile 372 | conflict |
| Ile 358 | Val 375 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -46 | - | initiating methionine |
| Lys -45 | - | expression tag |
| Phe -44 | - | expression tag |
| Leu -43 | - | expression tag |
| Val -42 | - | expression tag |
| Asn -41 | - | expression tag |
| Val -40 | - | expression tag |
| Ala -39 | - | expression tag |
| Leu -38 | - | expression tag |
| Val -37 | - | expression tag |
| Phe -36 | - | expression tag |
| Met -35 | - | expression tag |
| Val -34 | - | expression tag |
| Val -33 | - | expression tag |
| Tyr -32 | - | expression tag |
| Ile -31 | - | expression tag |
| Ser -30 | - | expression tag |
| Tyr -29 | - | expression tag |
| Ile -28 | - | expression tag |
| Tyr -27 | - | expression tag |
| Ala -26 | - | expression tag |
| Asp -25 | - | expression tag |
| Tyr -24 | - | expression tag |
| Lys -23 | - | expression tag |
| Asp -22 | - | expression tag |
| Asp -21 | - | expression tag |
| Asp -20 | - | expression tag |
| Asp -19 | - | expression tag |
| Lys -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Nh2 12 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 153352.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.7 | |
| All* | Total formula weight | 153739.3 |
