7P00

Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex

7P00 の概要

• エントリーDOI: 10.2210/pdb7p00/pdb
• EMDBエントリー: 13140
• 分子名称: Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: receptor, complex, eukaryotic protein, membrane protein
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 153615.19

構造登録者

Thom, C.,Ehrenmann, J.,Vacca, S.,Waltenspuhl, Y.,Schoppe, J.,Medalia, O.,Pluckthun, A. (登録日: 2021-06-29, 公開日: 2021-12-15)

• 主引用文献: Thom, C.,Ehrenmann, J.,Vacca, S.,Waltenspuhl, Y.,Schoppe, J.,Medalia, O.,Pluckthun, A.; Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features.; Sci Adv, 7:eabk2872-eabk2872, 2021; PubMed: 34878828; DOI: 10.1126/sciadv.abk2872

実験手法

ELECTRON MICROSCOPY (2.71 Å)