7OVY

Crystal structure of a dimeric based inhibitor JG34 in complex with the MMP-12 catalytic domain

Summary for 7OVY

• Entry DOI: 10.2210/pdb7ovy/pdb
• Descriptor: Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (7 entities in total)
• Functional Keywords: hydrolase, hydrolase-inhibitor crystal complex, hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 19407.69

Authors

Ciccone, L.,Rossello, A.,Vera, L.,Nuti, E.,Stura, E.A. (deposition date: 2021-06-15, release date: 2021-10-27, Last modification date: 2024-01-31)

• Primary citation: Cuffaro, D.,Camodeca, C.,Tuccinardi, T.,Ciccone, L.,Bartsch, J.W.,Kellermann, T.,Cook, L.,Nuti, E.,Rossello, A.; Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors.; Acs Med.Chem.Lett., 12:1787-1793, 2021; PubMed: 35111280; DOI: 10.1021/acsmedchemlett.1c00411

Experimental method

X-RAY DIFFRACTION (1.24 Å)