7OV8

Crystal structure of pig purple acid phosphatase in complex with 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) and glycerol

7OV8 の概要

• エントリーDOI: 10.2210/pdb7ov8/pdb
• 関連するPDBエントリー: 7OV2 7OV3
• 分子名称: Tartrate-resistant acid phosphatase type 5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (10 entities in total)
• 機能のキーワード: purple acid phosphatase, metallohydrolases, osteoporosis, fragment-based drug design, metal binding protein, hydrolase
• 由来する生物種: Sus scrofa (Pig)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40911.04

構造登録者

Feder, D.,McGeary, R.P.,Guddat, L.W.,Schenk, G. (登録日: 2021-06-14, 公開日: 2022-03-23, 最終更新日: 2024-10-09)

• 主引用文献: Feder, D.,Mohd-Pahmi, S.H.,Hussein, W.M.,Guddat, L.W.,McGeary, R.P.,Schenk, G.; Rational Design of Potent Inhibitors of a Metallohydrolase Using a Fragment-Based Approach.; Chemmedchem, 16:3342-3359, 2021; PubMed: 34331400; DOI: 10.1002/cmdc.202100486

実験手法

X-RAY DIFFRACTION (2.3 Å)