7OK8

Crystal structure of human carbonic anhydrase II with 4-((2-hydroxy-3-(phenylselanyl)propyl)thio)benzenesulfonamide

This is a non-PDB format compatible entry.

Summary for 7OK8

• Entry DOI: 10.2210/pdb7ok8/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: carbonic anhydrase ii, metalloenzyme, sulfonamide, selenium, organoselenide, inhibitor, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 30251.35

Authors

Angeli, A.,Ferraroni, M. (deposition date: 2021-05-17, release date: 2022-06-01, Last modification date: 2024-02-07)

• Primary citation: Tanini, D.,Carradori, S.,Capperucci, A.,Lupori, L.,Zara, S.,Ferraroni, M.,Ghelardini, C.,Mannelli, L.,Micheli, L.,Lucarini, E.,Carta, F.,Angeli, A.,Supuran, C.T.; Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action.; Eur.J.Med.Chem., 225:113793-113793, 2021; PubMed: 34507012; DOI: 10.1016/j.ejmech.2021.113793

Experimental method

X-RAY DIFFRACTION (1.43 Å)