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7OJQ

Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 7

Summary for 7OJQ
Entry DOI10.2210/pdb7ojq/pdb
DescriptorAcyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, 2-(2-chlorophenyl)sulfanyl-~{N}-[(4-cyanophenyl)methyl]-~{N}-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]ethanamide (3 entities in total)
Functional Keywordsacyltransferase, fatty acids, lipid a, left-handed parallel beta-helix, transferase
Biological sourcePseudomonas aeruginosa (strain PA7)
Total number of polymer chains3
Total formula weight86231.71
Authors
Ryan, M.D.,Parkes, A.L.,Southey, M.,Andersen, O.A.,Zahn, M.,Barker, J.,DeJonge, B.L.M. (deposition date: 2021-05-17, release date: 2021-10-13, Last modification date: 2024-01-31)
Primary citationRyan, M.D.,Parkes, A.L.,Corbett, D.,Dickie, A.P.,Southey, M.,Andersen, O.A.,Stein, D.B.,Barbeau, O.R.,Sanzone, A.,Thommes, P.,Barker, J.,Cain, R.,Compper, C.,Dejob, M.,Dorali, A.,Etheridge, D.,Evans, S.,Faulkner, A.,Gadouleau, E.,Gorman, T.,Haase, D.,Holbrow-Wilshaw, M.,Krulle, T.,Li, X.,Lumley, C.,Mertins, B.,Napier, S.,Odedra, R.,Papadopoulos, K.,Roumpelakis, V.,Spear, K.,Trimby, E.,Williams, J.,Zahn, M.,Keefe, A.D.,Zhang, Y.,Soutter, H.T.,Centrella, P.A.,Clark, M.A.,Cuozzo, J.W.,Dumelin, C.E.,Deng, B.,Hunt, A.,Sigel, E.A.,Troast, D.M.,DeJonge, B.L.M.
Discovery of Novel UDP- N -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa .
J.Med.Chem., 64:14377-14425, 2021
Cited by
PubMed: 34569791
DOI: 10.1021/acs.jmedchem.1c00888
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.87 Å)
Structure validation

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