7OFS

Structure of SARS-CoV-2 Papain-like protease PLpro in complex with 4-(2-hydroxyethyl)phenol

7OFS の概要

• エントリーDOI: 10.2210/pdb7ofs/pdb
• 関連するPDBエントリー: 7NFV 7OFT 7OFU
• 分子名称: Papain-like protease nsp3, ZINC ION, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: papain-like protease sars-cov-2 hydrolase zinc binding protein, hydrolase
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36168.50

構造登録者

Srinivasan, V.,Werner, N.,Falke, S.,Guenther, S.,Reinke, P.,Ewert, W.,Sprenger, J.,Koua, F.,Brognaro, H.,Ullah, N.,Andaleeb, H.,Perbandt, M.,Alves Franca, B.,Schwinzer, M.,Wang, M.,Lieske, J.,Ginn, H.,Lane, T.J.,Yefanov, O.,Gelisio, L.,Hakanpaeae, J.,Saouane, S.,Tolstikova, A.,Groessler, M.,Fleckenstein, H.,Trost, F.,Wolf, M.,Lorenzen, K.,Schubert, R.,Han, H.,Schmidt, C.,Brings, L.,Galchenkova, M.,Gevorkov, Y.,Li, C.,Perk, A.,Awel, S.,Wahab, A.,Choudary, I.,Turk, D.,Hinrichs, W.,Chapman, H.N.,Meents, A.,Betzel, C. (登録日: 2021-05-05, 公開日: 2021-05-12, 最終更新日: 2024-01-31)

• 主引用文献: Srinivasan, V.,Brognaro, H.,Prabhu, P.R.,de Souza, E.E.,Gunther, S.,Reinke, P.Y.A.,Lane, T.J.,Ginn, H.,Han, H.,Ewert, W.,Sprenger, J.,Koua, F.H.M.,Falke, S.,Werner, N.,Andaleeb, H.,Ullah, N.,Franca, B.A.,Wang, M.,Barra, A.L.C.,Perbandt, M.,Schwinzer, M.,Schmidt, C.,Brings, L.,Lorenzen, K.,Schubert, R.,Machado, R.R.G.,Candido, E.D.,Oliveira, D.B.L.,Durigon, E.L.,Niebling, S.,Garcia, A.S.,Yefanov, O.,Lieske, J.,Gelisio, L.,Domaracky, M.,Middendorf, P.,Groessler, M.,Trost, F.,Galchenkova, M.,Mashhour, A.R.,Saouane, S.,Hakanpaa, J.,Wolf, M.,Alai, M.G.,Turk, D.,Pearson, A.R.,Chapman, H.N.,Hinrichs, W.,Wrenger, C.,Meents, A.,Betzel, C.; Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.; Commun Biol, 5:805-805, 2022; PubMed: 35953531; DOI: 10.1038/s42003-022-03737-7

実験手法

X-RAY DIFFRACTION (1.9 Å)